Solubility Test of MK-2866 (Ostarine) in Water

SARM MK-2866 (Ostarine) is widely used for muscle gain and muscle mass maintenance. There are various forms of MK-2866 products, ranging from MK-2866 powder to tablets, capsules, and solutions, with significant price differences between them. Notably, MK-2866 solution tends to be much more expensive. Being able to prepare your own MK-2866 solution could lead to substantial cost savings. This experiment investigates the solubility of MK-2866 in water in preparation for personal solution formulation.

Materials:

Sample: 1 gram of MK-2866 powder

Solvent: Purified (deionized) water

Equipment:

Electronic balance

Glass beaker (50 mL)

Stirring rod

Experimental Procedure:

Step 1: Weigh 1 gram of MK-2866 powder and place it into the beaker.

Step 2: Add 1 mL of deionized water and stir with the rod. Observe the dissolution.

Step 3: If no dissolution is observed, add another 1 mL of water (total 2 mL), stir, and continue observation.

Step 4: If the sample still doesn't dissolve, increase the total water volume directly to 10 mL, stir thoroughly, and record the results.

Observations and Results

Test with 1 mL of Water:

After adding 1 mL of water, stir with the rod.

Observation: MK-2866 powder showed no visible dissolution and even formed a coating around the water droplets.

Test with 2 mL of Water:

Add another 1 mL of water, bringing the total to 2 mL.

Stir and observe the state of the powder.

Observation: 2 mL of water didn't dissolve the powder. After stirring, the powder was seen floating on top of the water.

Test with 10 mL of Water:
At this point, it's becoming clear that MK-2866 might not dissolve in water at all. So let's increase the water volume to test this theory.

Increase the total water volume directly to 10 mL.

Stir thoroughly until the powder is fully dispersed, then observe.

Observation: The solubility hasn't improved. The powder is still floating on the surface and has not dissolved. So, MK-2866 is not soluble in water.

Result Analysis

From the above experimental steps and observations, we can conclude that MK-2866 is not soluble in water. Therefore, using water alone as a solvent is not suitable for preparing oral solutions or injectable formulations.

This experiment confirms the extremely poor solubility of MK-2866 in water, which has important implications for formulation development. It is recommended to use lipid-based solvents (such as MCT oil or PEG-based solvents) or organic solvents (such as ethanol or DMSO) to improve solubility.