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GPCRMS Nitrogen equipment for MS(Mass Spectrometry) testing

23 Apr,2025

In our daily laboratory work, mass spectrometry (MS) is an essential and frequently used analytical tool. To ensure the proper functioning of the mass spectrometer and the accuracy of the data, a reliable gas supply is crucial—especially nitrogen. Nitrogen not only serves as a carrier gas in MS systems but also plays a key role in aiding sample ionization, thereby improving analytical sensitivity and stability. Therefore, a stable and pure nitrogen supply is vital for MS testing.

Nitrogen for MS testing 1

To meet this requirement, our lab has introduced a dedicated nitrogen generator. Although this equipment is quite noisy during operation, it is an indispensable part of our daily MS testing. The main function of the nitrogen generator is to extract high-purity nitrogen from ambient air and deliver it at a steady flow rate and pressure to the mass spectrometer. Compared to purchasing nitrogen cylinders externally, this self-sufficient method is not only more cost-effective but also significantly reduces long-term expenses.

Nitrogen for MS testing 2

More importantly, generating nitrogen on-site helps avoid the risk of interrupted experiments due to unstable external supply. In the past, when purchased nitrogen was delivered late or gas cylinders needed to be replaced, experiments often had to be halted, which negatively impacted our workflow and project timelines. Now, with the nitrogen generator in place, we can ensure a continuous and stable supply, greatly enhancing the consistency and reliability of our experiments.

Nitrogen for MS testing 3

Although the machine is quite noisy during operation, this minor inconvenience is entirely acceptable given the overall benefits. In fact, we are also considering installing a soundproof enclosure or optimizing its placement to reduce its impact on the working environment, thereby achieving a balance between efficiency and comfort.


In summary, the introduction of the nitrogen generator represents a significant investment in the lab’s equipment and operational efficiency. It not only enhances the stability and continuity of MS testing but also provides clear advantages in cost control and resource management. Despite the noise, this “loud” machine has become a reliable partner in our scientific research.