Enclo vs Clomiphene: Who's the Rising Star of PCT in Bodybuilding?

In the world of bodybuilding and performance enhancement, Post Cycle Therapy (PCT) is an essential phase that cannot be overlooked. After using anabolic-androgenic steroids (AAS), the body’s natural testosterone production is suppressed, making it crucial to restore hormonal balance in order to maintain gains and protect long-term health.

Clomiphene—commonly known as Clomid—has long been the go-to option for PCT. However, a newer alternative, Enclomiphene (often shortened to Enclo), is rapidly gaining popularity among fitness enthusiasts and bodybuilders.

So, what makes Enclo a serious contender—and potentially a superior replacement—for Clomiphene?

1. Active Ingredient Comparison: Enclo Has the Clear Advantage

Clomiphene is actually a mixture of two isomers:

Enclomiphene (the more active and beneficial one)

Zuclomiphene (less active, longer half-life, and more prone to side effects)

Traditional Clomid contains about 62% Enclomiphene and 38% Zuclomiphene. The latter is associated with side effects like mood swings, blurred vision, and even anxiety or depression.

In contrast, Enclomiphene is the pure active isomer, which translates to:

Fewer side effects

More direct and efficient testosterone recovery

Shorter half-life, making it easier to manage during PCT

2. Testosterone Boosting Effect: Enclo is More Targeted and Efficient

Enclomiphene works by stimulating the hypothalamic-pituitary-testicular axis (HPTA), increasing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)—both crucial for natural testosterone production.

Studies show that:

Enclo can significantly raise natural testosterone levels in a short time

It has less impact on estrogen levels, reducing the risk of gynecomastia (gyno)

It helps restore sperm production and libido more quickly than Clomid

3. Emotional and Mental Effects: Enclo is Gentler on the Mind

Many users report negative psychological effects from Clomid, including:

Depression or low mood

Irritability

Decreased sleep quality

These effects are largely attributed to Zuclomiphene's influence on the nervous system. Since Enclo is a single-isomer formulation, it is less likely to disturb the central nervous system, making it a more stable and emotionally tolerable option during PCT—especially important for those who value their mental state during recovery.

4. Legal Status and Accessibility: Enclo Still in a Grey Zone

Enclomiphene has passed certain clinical trials in the U.S. and is used in research settings, but it hasn’t been widely approved for therapeutic use globally. As such, it exists in a legal grey area—it’s available for purchase, but users must assume the associated risks.

Clomiphene, on the other hand, is FDA-approved and widely accessible, with clearly established medical usage standards.

However, this “pharmaceutical status” of Clomid may actually limit its flexibility within the bodybuilding community, according to some users.

Final Thoughts: Who Wins the Crown? It Depends on Your Goals and Response

In summary, Enclomiphene is emerging as a strong contender in PCT due to its higher selectivity, lower side effect profile, and more effective hormonal recovery.

That said, Clomid is far from obsolete. For those on a tighter budget or who prefer a well-established, regulated medication, Clomid remains a valid and effective choice.

Ultimately, the decision between Enclo and Clomid reflects a choice between stable tradition and efficient innovation. The key is understanding your own body and choosing the recovery strategy that aligns best with your individual needs.