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RAD140+MK677 Cycle Guide: Effective Muscle Building Plan for Most Users

18 Apr,2025

Muscle building is one of the main goals for many fitness enthusiasts and athletes. To achieve this, many people turn to various substances and supplements to accelerate muscle growth and recovery, with RAD140 (Testolone) and MK677 (Ibutamoren) being two widely used options. By using these substances in a well-structured cycle, combined with proper nutrition, significant muscle gains and performance improvements can be achieved. However, understanding how to use them scientifically, control side effects, and ensure safety is the key to success.

In this article, we will introduce a 12-week RAD140 and MK677 cycle and recommend adding Berberine to effectively control blood sugar levels, especially when MK677 may impact blood sugar.

1. Overview of RAD140 and MK677

RAD140: RAD140 is a selective androgen receptor modulator (SARM) that promotes muscle growth and increases strength by mimicking the effects of testosterone. Compared to steroids, RAD140 has fewer side effects, particularly in terms of liver and cardiovascular health. It is particularly suitable for users who want to increase lean mass while minimizing excess water retention or fat accumulation.

MK677: MK677 is an oral growth hormone-releasing hormone (GHRH) mimic that stimulates the body to naturally produce more growth hormone (GH) and insulin-like growth factor (IGF-1). These hormones play a crucial role in muscle repair, fat burning, sleep quality, and overall recovery. MK677 also increases appetite and promotes fat breakdown, making it especially useful during muscle-building phases.

2. Muscle-Building Cycle Plan

Week 1-8: Base Cycle

RAD140 10mg/day: The daily dose of RAD140 is set at 10mg, which is a moderate dose that effectively promotes muscle growth without overstimulating the body or causing unnecessary side effects.

MK677 10mg/day: MK677 is dosed at 10mg daily during this cycle. This dosage can significantly increase growth hormone levels, enhancing muscle recovery and repair while helping to increase appetite and promote fat metabolism.

Enclomiphene 6.25mg/day: Enclomiphene is a selective estrogen receptor modulator (SERM) commonly used to restore natural testosterone levels, especially when using steroids or SARMs. It helps maintain testosterone levels, preventing issues such as decreased libido or low energy that might occur during the cycle.

This phase is the base muscle-building period, where RAD140 and MK677 work together to help most users rapidly increase muscle mass while keeping fat accumulation low. Enclomiphene helps maintain testosterone levels, preventing negative effects from using MK677.

Week 9-12: Post-Cycle Adjustment

MK677 10mg/day (Optional): In this phase, MK677 dosage can be maintained or reduced to an optional 10mg/day. This phase focuses on adjusting and optimizing the body's response, ensuring continued muscle-building progress.

Enclomiphene 12.5mg/day: To better restore testosterone levels, Enclomiphene dosage can be increased to 12.5mg/day, helping to maintain hormonal balance and prevent excessive testosterone decline.

3. Blood Sugar Control: Adding Berberine

MK677 may cause slight increases in blood sugar levels due to its stimulation of insulin-like growth factor (IGF-1), which can affect insulin sensitivity. Therefore, it is recommended to add Berberine to the cycle, a natural plant compound proven to effectively control blood sugar and improve insulin sensitivity.

Berberine Dosage: The recommended dosage is 500mg, taken 2-3 times per day, preferably after meals. Berberine helps regulate blood sugar levels, reducing the blood sugar fluctuations caused by MK677 and improving overall metabolic efficiency, further enhancing muscle-building effects.

4. Other Supplements

To improve overall health and muscle-building results, the following supplements can be used alongside the RAD140+MK677 cycle:

TUDCA (250-500mg/day): TUDCA is a liver protection agent that helps detoxify the liver and supports liver function, especially during prolonged SARM use.

NAC (600-1200mg/day): NAC has powerful antioxidant properties that help neutralize free radicals in the body, reducing oxidative stress from intense workouts.

Omega-3 (2-3g/day): Omega-3 fatty acids help reduce inflammation, promote cardiovascular health, and provide essential fats for muscle-building.

Zinc (25-50mg/day): Zinc is crucial for immune function and metabolism, helping to maintain healthy testosterone levels.

Vitamin D3 (2000-5000 IU/day): Vitamin D3 supports bone health and enhances muscle function.

Magnesium (200-400mg/day): Magnesium improves sleep quality and reduces muscle cramps.

5. Important Notes

Monitor Body Response: When using any supplements or medications, it is important to regularly monitor indicators such as blood sugar, blood pressure, and testosterone levels to ensure your body's response remains within acceptable limits.

Diet and Training: A balanced diet and proper training remain the core of muscle building. Supplements and substances should only be used as an aid.

Safety First: The use of any supplement or substance should be done under the guidance of a doctor or professional to ensure safe and responsible use.

By using RAD140 and MK677 appropriately, and adding Berberine to control blood sugar levels, combined with a scientific diet and training plan, users can achieve significant muscle-building results within 12 weeks while minimizing side effects and health risks.